Nicotinamide Riboside (NR) is a next-generation form of vitamin B3; its metabolism is unique compared to other, more commonly used forms of vitamin B3, as it more effectively increases nicotinamide adenine dinucleotide (NAD+) levels. NAD+ is an essential factor in proper cellular energy metabolism. NAD+ plays a fundamental role in cellular repair mechanisms. In fact, NAD+ depletion is increasingly associated with aging, exposure to metabolic stress factors, and diseases. Metabolic stress factors related to NAD+ depletion include excessive alcohol consumption, prolonged UV exposure, immune stress, and sedentary lifestyles.

Moreover, one of NR’s roles as a precursor to NAD+ is the activation of a class of enzymatic proteins, the sirtuins, associated with a wide range of functions related to cellular maintenance, me-tabolism, and healthy aging.

The formula is enriched with vitamin C, which, as explained by one of the leading longevity researchers, David A. Sinclair, can stimulate the activity of specific enzymes (TET – ten-eleven trans-location) involved in activating genes associated with youthfulness